search
top
Currently Browsing: Defective Pharmaceuticals

Actonel – A Harmful Osteoporosis Drug

A pharmaceutical drug, otherwise called medicinal product, medicine or medication, is manufactured for purposes of medical diagnoses, prevention, treatment or cure of diseases. Three well-known FDA-approved medicines, under the class known as Bisphosphonate, are Fosamax, Actonel and Boniva – all for prevention and treatment of (post-menopausal) osteoporosis, a medical condition wherein bones turn fragile and brittle due to loss of tissue, an occurrence that usually results from deficiency in vitamin D, calcium or hormonal changes.

Women suffering from post-menopausal osteoporosis are prescribed with one of the three medicines mentioned to help decrease the fracture of bones in their body. In a test conducted, called the Fosamax Actonel Comparison Trial (FACT) trial, Fosamax edged Actonel in the manifestation of decrease in bone loss, seen through a substantial decrease in bone turnover and increases in mineralization.

Another study was conducted, though, which compared the performance and effectivity of the three drugs. The study showed that, while Boniva and Fosamax manifested desired results (that is, decrease of bone fractures) after two years of use, Actonel proved effective only after a year of intake, enabling researchers to confidently say that Actonel works much faster.

The result of this last study has only reassured University of Cincinnati Bone Health and Osteoporosis Center director Nelson B. Watts, MD and Women’s Health Center at The Cleveland Clinic director Holly Thacker, MD, in their decision of to prescribe Actonel over any other drug for treatment of osteoporosis.

In January of 2008, the US Food and Drug Administration issued a health alert, stating the possible risk associated with the use of bisphosphonates. These risks included serious bone, muscle and/or joint pains which may incapacitate a patient. Thus, use of any of the bisphosphonate drugs necessitated both physician and patient to fully understand the benefits and possible side-effects of the drugs.

Actonel, in particular, despite its benefits, is known to cause certain serious side-effects, such as femur fractures, rashes, skin reactions, hypersensitivity and osteonecrosis of the jaw. Actonel (with the generic name Risedronate sodium) was approved for distribution on March 27, 1998; it is manufactured by Procter & Gamble.

One side-effect caused by Actonel, which has resulted to lawsuits is Femur Fracture. On its website, the National Injury Law Center states that Actonel, indeed, is “linked to spontaneous femur fractures” and is, therefore, considered a harmful drug.

top